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pentobarbital will lessen the extent or result of nilotinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

Warning when discontinuing CYP3A4 inducers which are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may well boost and can lead to most likely fatal respiratory despair.

Hypnotic doses of such barbiturates will not seem to substantially impair uterine action for the duration of labor; comprehensive anesthetic doses of barbiturates minimize the force and frequency of uterine contractions; administration of sedative-hypnotic barbiturates for the mom for the duration of labor may perhaps result in respiratory melancholy while in the newborn

Contraindicated (1)pentobarbital will lower the level or influence of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is often a sensitive CYP3A4 substrate. Coadministration with robust or average CYP3A4 inducers is contraindicated.

pentobarbital will reduce the level or result of ixabepilone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will lower the level or result of cyclosporine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

Keep an eye on Carefully (2)pentobarbital will decrease the extent or outcome of oliceridine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. If coadministration with a CYP3A4 inducer is necessary, think about growing oliceridine dose till secure drug consequences are reached; check for signs of opioid withdrawal.

pentobarbital will lower the extent or impact of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

pentobarbital will lessen the extent or impact of cinacalcet by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

pentobarbital will decrease the level or result of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unfamiliar.

Withdrawal signs or symptoms may perhaps arise from abrupt cessation right after prolonged use in the dependent human being and will lead to delirium, convulsions, And maybe Demise; barbiturates ought to be withdrawn steadily from any individual known to be taking too much dosage above lengthy amounts of time

pentobarbital will decrease the level get more info or effect of lopinavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will lessen the level or result of nelfinavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

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